Fertility 101: Understanding your options! Thursday, April 08, 2025 06:00 pm- 07:00 pm

ICSI vs IVF: When is ICSI Genuinely Indicated?

When you are on the path towards parenthood but see yourself trying with no success, fertility treatments open up doors to achieve your dream. On your fertility journey, you will encounter two treatments that are usually suggested – IVF (In Vitro Fertilization) and ICSI (Intracytoplasmic Sperm Injection). While both these treatments are highly effective, you may still understandably ask: “IVF or ICSI – which is better?” Speaking plainly, neither treatment is universally “better” while medically, each serves a specific medical need. 

What is IVF treatment? 

This treatment involves the collection of eggs from the female’s ovarian follicles, and then combined with the sperm in a petri dish for fertilization. Fertilization occurs in a natural way. After the embryos develop, one or several are transferred to the uterus. IVF is as close to natural fertilization as possible, only the process is done outside the body. 

What is ICSI treatment? 

ICSI is an advanced technique, a step ahead of IVF. During this process, with the help of modern microscopic techniques, a sperm is selected and injected into a mature egg. This process is very effective in cases where the sperm cannot get to or through the egg on their own.  

ICSI vs IVF: How Are They Different?

The way an egg is fertilised is the main difference here:

 

Aspect IVF ICSI
How fertilization occurs Sperm fertilize eggs naturally in the lab An embryologist injects one sperm directly into the egg
Treated for Tubal issues, unexplained infertility, female-factor issues Male-factor infertility, previous fertilization failure
Cost Lower than ICSI Slightly higher because of lab expertise
Success rates A necessity of a higher quantity of healthy, motile sperm Accomplished with a lower quantity of sperm, even those obtained by surgery or from cryopreservation

 

When will doctors suggest IVF?

Doctors suggest IVF especially when natural conception cannot be effected. This can happen under medical conditions like blocked tubes, irregular ovulation, endometriosis or sperm problems that make conception difficult.

When will doctors suggest ICSI?

Usually in conditions such as low sperm count, poor sperm motility, and abnormal sperm, or when past IVF cycles did not result in fertilization.

Who is IVF recommended for?

Doctors suggest IVF, especially for women, when natural conception isn’t working even after simpler treatments.

Who is ICSI recommended for?

ICSI is usually recommended when the male partner suffers from low sperm count, immotile sperm, or sperm with abnormal shape, or when previous IVF cycles have failed, and when the sperm has to be surgically retrieved. 

What is the success rate of IVF and ICSI?

A woman’s age and ovulation issues, egg and sperm viability could be one among the many factors that could affect the success rates of IVF and ICSI fertility treatments.

ICSI, by its nature of being controlled, has slightly higher fertilization rates. Additionally, once fertilization occurs, the success rates of embryo development and pregnancy for both treatments are usually the same. 

What are the benefits of IVF treatment?

IVF is beneficial for:

  • Women with endometriosis, irregular or absent ovulation, blocked or damaged fallopian tubes, or PCOS.
  • Women experiencing early menopause or low egg reserve 
  • Older women who have a limited number of healthy eggs.
  • Couples with unexplained infertility can still try IVF and also have better control over the timing of treatment.

What are the benefits of ICSI treatment?

ICSI is opted for when:

  • The male companion has a low sperm count. 
  • Sperm motility is either slow or weak. 
  • The man suffers from obstructions, which hinder natural ejaculation. 
  • The partner’s infertility is unexplainable, and past treatments have not been effective.

Is ICSI more effective than IVF?

The inquiry “Is ICSI more effective than IVF?” does not always provide an absolute answer. What is important here is the reason for the treatment selection. The final decision is based on medical indications, taking into account semen parameters, egg quality, previous cycles, and overall reproductive health. 

Are babies born with IVF and ICSI normal?

Yes, studies have indicated that no such differences with respect to behavior or physiology are conclusively claimed about babies born with IVF and ICSI.

Health of children after IVF or ICSI

Infants born following either treatment show equal IQ, weight, growth, and development with the naturally born ones. What is important is to get in touch with the top fertility clinics in India for the most favourable results, whenever you choose to opt for ICSI or IVF treatment.

Which treatment is more successful, ICSI or IVF?

ICSI and IVF yield comparable chances of pregnancy. ICSI mainly increases the chances of fertilization only when a sperm issue is present. Used correctly, both treatments are of equal efficacy, as they depend on the particular fertility problem of the couple.

Potential risks and considerations of ICSI and IVF

  • Multiple pregnancies: IVF and ICSI both can result in the occurrence of multiple pregnancies, for instance, twins, triplets, etc. Every case will involve some risk to the mother and infants to a certain degree. 
  • Ovarian Hyperstimulation Syndrome: In rare cases, the treatment drugs itself may cause the ovaries to be over-stimulated, leading to their swelling and producing pain. 
  • Egg retrieval risks: The procedure of egg retrieval is prone to small risk of complications like bleeding, infection, or damage to the bowel or bladder. 
  • Emotional stress: At times, fertility treatments can be a source of emotional stress for you, as nobody can promise that every fertility treatment will end up in the delivery of a healthy baby.

In specific circumstances, both treatments may not succeed. There is still no guarantee for fertilization even when there is a direct fusion of a healthy sperm and a healthy egg. However, with both IVF or ICSI, once the fertilization of the egg takes place, your pregnancy journey will start.

What will be the future of fertility treatments?

With evolving technology, preimplantation genetic testing (PGT), together with IVF and ICSI, will ensure a stress-free pregnancy, and lower the risk of failure during these procedures.

Need help deciding between ICSI or IVF?

The debate of ICSI vs IVF does not reduce to a simple “ICF or ICSI – who is the winner?”, but rather what is the most suitable in a given situation. For partners with male-factor problems or past failure of IVF fertilization, ICSI can be a miracle. For the rest, IVF remains a good, effective, and cleaner first choice. At Luma fertility, decisions are made only after thorough consultations, detailed medical testing, and clear discussions around the pros and cons. Get in touch with us for a viable solution to your fertility challenges.

Still thinking about what your fertility journey could be? Start with 10% off your first consultation

Contact our fertility care specialist today to know more.

Still thinking about what your fertility journey could be? Start with 10% off your first consultation.

Contact our fertility care specialist today to know more.
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